Pharma intermediate
2,3,4-Trichloro Nitro Benzene (2,3,4-TCNB) Supplier & Distributor in India & Worldwide
Chelora Agrochem is a trusted 2,3,4-Trichloro Nitro Benzene (2,3,4-TCNB) supplier and distributor in India, connecting buyers with high-purity material sourced from leading, quality-approved manufacturers. Our 1,2,3-trichloro-4-nitrobenzene meets 98% min purity with controlled isomer content, full documentation and reliable supply across India and to buyers worldwide.
As a specialised distributor of chemical products, we do not manufacture in-house — instead we source only from reliable, audited manufacturers, giving you dependable material, competitive pricing and a single point of contact for all your 2,3,4-TCNB requirements, backed by COA, MSDS and TDS on every order.
- CAS number
- 17700-09-3
- Formula
- C6H2Cl3NO2
- Molecular weight
- 226.44 g/mol
- Purity
- 98% min
Quick product specifications
2,3,4-Trichloro Nitro Benzene at a glance
Identifiers, physical data and trade codes for 2,3,4-TCNB. Batch-specific figures are confirmed on the Certificate of Analysis supplied with each consignment, in India and on export shipments alike.
- Chemical name
- 2,3,4-Trichloro Nitro Benzene
- CAS number
- 17700-09-3
- Molecular formula
- C6H2Cl3NO2
- Molecular weight
- 226.44 g/mol
- IUPAC name
- 1,2,3-Trichloro-4-nitrobenzene
- HS code
- 2904 99National subheading as per destination
- UN number
- Typically UN 2811Toxic solid, organic, n.o.s. · Class 6.1 — confirm on SDS
- Appearance
- Pale yellow crystalline solid
- Melting point
- 53–56 °C
- Boiling point
- High-boilingDistilled under reduced pressure
- Flash point
- Above 110 °CCombustible solid
- Solubility
- Practically insoluble in waterSoluble in common organic solvents
- Purity
- 98% min
- Synonyms
- 2,3,4-TCNB1,2,3-Trichloro-4-nitrobenzene · 2,3,4-Trichloronitrobenzene
- Product form
- Crystals or flakes
- Main downstream
- 2,3,4-Trifluoronitrobenzene
- Odour
- Faint, aromatic
- Documentation
- COA, MSDS & TDSSupplied with every order
Product overview
What is 2,3,4-Trichloro Nitro Benzene?
2,3,4-Trichloro Nitro Benzene (2,3,4-TCNB) is a trichlorinated nitroaromatic used mainly as the precursor of 2,3,4-trifluoronitrobenzene, the starting material for the fluoroquinolone antibiotics ofloxacin and levofloxacin.
With the formula C6H2Cl3NO2 (CAS 17700-09-3), 2,3,4-TCNB is a pale yellow crystalline solid that melts at about 55 °C and is practically insoluble in water. It is made by nitrating 1,2,3-trichlorobenzene.
The three adjacent chlorines are exchanged for fluorine in a halogen-exchange reaction; isomer purity at this stage carries straight through to the fluorinated intermediate, which is why quinolone producers specify 2,3,4-TCNB by isomer profile as closely as by assay.
How it is made
1,2,3-Trichlorobenzene is nitrated with mixed nitric and sulfuric acid. The 4-nitro product is separated from minor isomers and purified by crystallisation.
What that means for your process
- Three exchangeable chlorines for halogen exchange to fluorine
- Isomer content controlled to grade, checked by GC
- Low moisture for anhydrous fluorination
- Free-flowing crystals for easy charging
Applications
What is 2,3,4-Trichloro Nitro Benzene used for?
2,3,4-TCNB is used almost entirely as a chemical intermediate. Its main applications, industry by industry, include:
Fluoroquinolone antibiotics
The main use. Fluorinated to 2,3,4-trifluoronitrobenzene, the building block for ofloxacin and levofloxacin.
- Precursor of 2,3,4-trifluoronitrobenzene
- Route to ofloxacin and levofloxacin intermediates
- Other fluorinated quinolone building blocks
Agrochemicals
Used where a polychlorinated or polyfluorinated nitroaromatic is needed in crop-protection synthesis.
- Polyhalogenated aniline intermediates
- Fluorinated agro building blocks
Fine chemicals
Specified by custom-synthesis houses for halogenated aromatic intermediates.
- 2,3,4-Trichloroaniline by hydrogenation
- Custom synthesis and research scale-up
Process route
How is 2,3,4-TCNB used in quinolone manufacturing?
2,3,4-TCNB undergoes halogen exchange with potassium fluoride in a polar aprotic solvent to give 2,3,4-trifluoronitrobenzene. That trifluorinated nitroaromatic is the starting material for the benzoxazine core of ofloxacin and levofloxacin.
2,3,4-Trichloro Nitro Benzene
Charged as the trichloro compound. Assay and isomer content decide fluorinated product purity.
C6H2Cl3NO2Halogen exchange
Heated with anhydrous potassium fluoride in sulfolane or a similar solvent.
KF / sulfolane2,3,4-Trifluoronitrobenzene
The fluorinated intermediate, built into the quinolone ring system.
C6H2F3NO2Antibiotic API
Ring construction gives ofloxacin and levofloxacin.
LevofloxacinIn depth
2,3,4-Trichloro Nitro Benzene applications by industry
Below is a detailed breakdown of where 2,3,4-TCNB is used and the role it plays in each downstream product.
| Industry | Typical downstream products | Role of 2,3,4-TCNB |
|---|---|---|
| Pharmaceuticals | 2,3,4-Trifluoronitrobenzene, ofloxacin, levofloxacin | Precursor |
| Agrochemicals | Polyhalogenated aromatic intermediates | Intermediate |
| Fine chemicals | 2,3,4-Trichloroaniline and custom molecules | Building block |
Safety
Is 2,3,4-Trichloro Nitro Benzene hazardous?
Yes. 2,3,4-TCNB is harmful if swallowed and can be absorbed through the skin, may cause methaemoglobinaemia at high exposure, and is toxic to aquatic life with long-lasting effects. With correct PPE, ventilation and storage it is safely handled in industry.
2,3,4-TCNB should be stored in sealed containers in a cool, dry, ventilated place away from heat, strong bases, reducing agents and oxidisers, and handled with gloves, goggles and dust respiratory protection. Prevent release to drains and waterways. A full MSDS is supplied with every order.
Signal word: Warning
Harmful if swallowed · may affect the blood · toxic to aquatic life with long-lasting effects
Safe-handling essentials
- Gloves, goggles and protective clothing at all times
- Dust respirator; use local exhaust ventilation
- Avoid skin contact — nitroaromatics are absorbed through the skin
- Keep packs sealed, cool and dry
- Store away from strong bases, reducing agents and oxidisers
- Never allow release to drains, soil or waterways
- Transport as a class 6.1 toxic solid — UN entry stated on the SDS
Grades
2,3,4-Trichloro Nitro Benzene grades & technical specifications
We supply 2,3,4-TCNB in a standard grade suited to halogen-exchange fluorination for quinolone intermediates.
| Parameter | Specification |
|---|---|
| Assay (purity) | 98% min |
| Appearance | Pale yellow crystals |
| Other trichloronitrobenzene isomers | 1.0% max |
| Dichloronitrobenzenes | 0.5% max |
| Melting range | 53–56 °C |
| Moisture | 0.2% max |
| Acidity | 0.01% max |
| Product form | Crystals or flakes |
Note: Values are representative. Batch-specific figures are provided on the Certificate of Analysis (COA) supplied with each consignment.
Supply
Packaging, MOQ & supply
From trial quantities for process validation to repeat container loads on contract — packed, documented and dispatched to your plant in India or overseas.
Packaging
25 or 50 kg HDPE-lined bags or fibre drums, palletised and shrink-wrapped.
Minimum order quantity
Flexible — single drums or bags for trials through to full-container loads.
Shelf life
Long shelf life in sealed, unopened packs stored cool, dry and out of direct light.
Dispatch
Pan-India dispatch and worldwide export with complete dangerous-goods documentation and logistics support.
Why buy from us
Why choose Chelora as your 2,3,4-TCNB supplier?
As an established 2,3,4-Trichloro Nitro Benzene supplier and distributor based in India and shipping worldwide, we work with a wide network of trusted manufacturers to combine consistent quality with dependable service. More about Chelora Agrochem.
High purity, every batch
98% min assay, sourced only from quality-approved manufacturers we have worked with and audited.
Full documentation
COA, MSDS and TDS travel with every order, so your QA and EHS teams are never chasing paperwork.
Reliable bulk supply, flexible MOQ
Single packs for process trials through to repeat container loads on schedule.
Worldwide supply
Export-grade packing, dangerous-goods documentation and on-time dispatch to plants across Asia, the Middle East, Europe, Africa and the Americas.
Technical & safe-handling support
Guidance on storage, PPE and process fit from a team that knows nitroaromatic intermediates.
One point of contact
Source 2,3,4-TCNB alongside your other intermediates — one enquiry, one team, one invoice.
Ordering
How to order 2,3,4-Trichloro Nitro Benzene from Chelora
Ordering is simple and fast — most enquiries are answered with pricing and availability within 24 hours.
- 1
Send your enquiry
Tell us the grade, quantity and application you are buying for.
- 2
Receive a quotation
We send pricing along with the COA and MSDS for your review.
- 3
Request a sample
Test suitability for your process before you commit to a bulk order.
- 4
Confirm the order
Lock in quantity, packaging and delivery preference.
- 5
Dispatch & tracking
We dispatch with full documentation and keep you updated until delivery.
Documentation
2,3,4-Trichloro Nitro Benzene MSDS & COA
A summary of key safety information and a representative Certificate of Analysis. The complete 16-section Safety Data Sheet and the actual batch COA are supplied with each shipment — and both are sent with your quotation when you ask for a quote.
Safety data summary (MSDS)
| Section | Details |
|---|---|
| Hazard classification | Acute toxicity cat. 4 (oral); aquatic chronic cat. 2 — further classifications on the SDS |
| Signal word | Warning |
| First aid — inhalation | Move to fresh air; seek medical help. Watch for signs of methaemoglobinaemia (blue lips or nails) |
| First aid — skin | Remove contaminated clothing; wash thoroughly with soap & water |
| First aid — eyes | Rinse with water for several minutes; get medical advice |
| Handling | Use PPE; avoid dust, vapour and skin contact; ventilate |
| Storage | Cool, dry, sealed; away from heat, bases, reducing agents & oxidisers |
| Environment | Toxic to aquatic life; prevent release to drains / waterways |
| Transport | Class 6.1 toxic solid; typically UN 2811 — confirm on SDS |
Certificate of Analysis (representative)
| Test parameter | Specification | Method |
|---|---|---|
| Assay (purity) | 98% min | GC |
| Appearance | Pale yellow crystals | Visual |
| Isomers | 1.0% max | GC |
| Melting range | 53–56 °C | Capillary |
| Moisture | 0.2% max | Karl Fischer |
| Acidity | 0.01% max | Titration |
The actual batch COA is supplied with each shipment.
FAQ
Frequently asked questions
Common questions from buyers specifying 2,3,4-TCNB for quinolone and fine-chemical production.
What is 2,3,4-Trichloro Nitro Benzene used for?
2,3,4-TCNB is used mainly to make 2,3,4-trifluoronitrobenzene, the starting material for the fluoroquinolone antibiotics ofloxacin and levofloxacin. It is also used in agrochemical and fine-chemical intermediates.
What is the CAS number of 2,3,4-TCNB?
The CAS number is 17700-09-3 and the molecular formula is C6H2Cl3NO2. It is also known as 1,2,3-trichloro-4-nitrobenzene or 2,3,4-trichloronitrobenzene.
How is 2,3,4-TCNB made?
1,2,3-Trichlorobenzene is nitrated with mixed nitric and sulfuric acid, and the 4-nitro product is separated from minor isomers and purified by crystallisation.
Is 2,3,4-Trichloro Nitro Benzene hazardous?
Yes. It is harmful if swallowed, can be absorbed through the skin, may cause methaemoglobinaemia at high exposure and is toxic to aquatic life. Handle it with proper PPE, ventilation and containment; we supply a full MSDS with every order.
How is 2,3,4-TCNB converted to 2,3,4-trifluoronitrobenzene?
By halogen exchange: it is heated with anhydrous potassium fluoride in a polar aprotic solvent such as sulfolane, often with a phase-transfer catalyst, so the three chlorines are replaced by fluorine.
How should 2,3,4-TCNB be stored?
In sealed bags or drums in a cool, dry, well-ventilated store, out of direct light and away from heat, strong bases, reducing agents and oxidisers.
Do you provide COA and MSDS for 2,3,4-TCNB?
Yes, we provide a batch-specific COA and MSDS with every order, plus technical support on request.
Do you supply and export 2,3,4-Trichloro Nitro Benzene?
Yes, we supply 2,3,4-TCNB across India and export internationally with complete dangerous-goods documentation, sourced from reliable manufacturers.
Request a quote or sample
Need a reliable 2,3,4-TCNB supplier?
Looking for a dependable 2,3,4-Trichloro Nitro Benzene (2,3,4-TCNB) supplier and distributor — in India or anywhere we export to? Tell us the grade and quantity you need — our team responds with competitive bulk pricing, samples and complete documentation (COA, MSDS, TDS) within 24 hours.
Or email source@cheloraagrochem.com