Fluoroquinolone intermediate
2,3,4-Trifluoro Nitro Benzene (2,3,4-TFNB) Supplier & Distributor in India & Worldwide
Chelora Agrochem is a trusted 2,3,4-Trifluoro Nitro Benzene (2,3,4-TFNB) supplier and distributor in India, connecting buyers with high-purity material sourced from leading, quality-approved manufacturers. Our 1,2,3-trifluoro-4-nitrobenzene meets 99% min purity with low residual chloro-fluoro content, full documentation and reliable supply across India and to buyers worldwide.
As a specialised distributor of chemical products, we do not manufacture in-house — instead we source only from reliable, audited manufacturers, giving you dependable material, competitive pricing and a single point of contact for all your 2,3,4-TFNB requirements, backed by COA, MSDS and TDS on every order.
- CAS number
- 771-69-7
- Formula
- C6H2F3NO2
- Molecular weight
- 177.08 g/mol
- Purity
- 99% min
Quick product specifications
2,3,4-Trifluoro Nitro Benzene at a glance
Identifiers, physical data and trade codes for 2,3,4-TFNB. Batch-specific figures are confirmed on the Certificate of Analysis supplied with each consignment, in India and on export shipments alike.
- Chemical name
- 2,3,4-Trifluoro Nitro Benzene
- CAS number
- 771-69-7
- Molecular formula
- C6H2F3NO2
- Molecular weight
- 177.08 g/mol
- IUPAC name
- 1,2,3-Trifluoro-4-nitrobenzene
- HS code
- 2904 99National subheading as per destination
- UN number
- Typically UN 2810Toxic liquid, organic, n.o.s. · Class 6.1 — confirm on SDS
- Appearance
- Clear pale yellow liquid
- Boiling point
- About 92 °CAt 20 mmHg
- Density
- About 1.54 g/mLAt 25 °C
- Flash point
- CombustibleValue stated on SDS
- Solubility
- Practically insoluble in waterMiscible with common organic solvents
- Purity
- 99% min
- Synonyms
- 2,3,4-TFNB1,2,3-Trifluoro-4-nitrobenzene · 2,3,4-Trifluoronitrobenzene
- Product form
- Liquid — drums, IBCs
- Main downstream
- Ofloxacin and levofloxacin
- Odour
- Aromatic
- Documentation
- COA, MSDS & TDSSupplied with every order
Product overview
What is 2,3,4-Trifluoro Nitro Benzene?
2,3,4-Trifluoro Nitro Benzene (2,3,4-TFNB) is a trifluorinated nitroaromatic and the established starting material for the fluoroquinolone antibiotics ofloxacin and levofloxacin. Its three adjacent fluorines and the nitro group become part of the benzoxazine core of these drugs.
With the formula C6H2F3NO2 (CAS 771-69-7), 2,3,4-TFNB is a pale yellow liquid that is practically insoluble in water and is distilled under reduced pressure. It is made from 2,3,4-trichloronitrobenzene by halogen exchange with potassium fluoride.
Partially fluorinated chloro-fluoro intermediates carry straight through into the antibiotic if they are not removed — which is why quinolone producers specify residual chloro-fluoro content as closely as assay.
How it is made
2,3,4-Trichloronitrobenzene is heated with anhydrous potassium fluoride in a polar aprotic solvent such as sulfolane, often with a phase-transfer catalyst. All three chlorines are exchanged for fluorine, and 2,3,4-TFNB is purified by vacuum distillation.
What that means for your process
- Three activated fluorines for ring construction
- Residual chloro-fluoro intermediates controlled, checked by GC
- Low moisture for anhydrous steps
- Vacuum-distilled liquid for consistent quality
Applications
What is 2,3,4-Trifluoro Nitro Benzene used for?
2,3,4-TFNB is used almost entirely as a chemical intermediate. Its main applications, industry by industry, include:
Fluoroquinolone antibiotics
The main use. The starting material for the benzoxazine core of ofloxacin and levofloxacin.
- Starting material for ofloxacin
- Starting material for levofloxacin
- Other trifluorophenyl quinolone intermediates
Agrochemicals
A polyfluorinated building block for crop-protection research and actives.
- 2,3,4-Trifluoroaniline by hydrogenation
- Fluorinated agro building blocks
Fine chemicals
Specified by custom-synthesis houses for polyfluorinated aromatic intermediates.
- Selective substitution chemistry
- Custom synthesis and research scale-up
Process route
How is 2,3,4-TFNB used in levofloxacin manufacturing?
The fluorine next to the nitro group is displaced to attach a hydroxypropyl side chain; reduction and ring closure then build the benzoxazine, onto which the quinolone ring is constructed to give ofloxacin, or levofloxacin when the chiral (S) side chain is used.
2,3,4-Trifluoro Nitro Benzene
Charged as the fluorinated nitroaromatic. Assay and chloro-fluoro content decide API purity.
C6H2F3NO2Substitution & reduction
The activated fluorine is displaced and the nitro group reduced.
SNAr / reductionBenzoxazine core
Ring closure gives the difluoro-benzoxazine intermediate.
BenzoxazineAntibiotic API
Quinolone ring construction gives ofloxacin or levofloxacin.
LevofloxacinIn depth
2,3,4-Trifluoro Nitro Benzene applications by industry
Below is a detailed breakdown of where 2,3,4-TFNB is used and the role it plays in each downstream product.
| Industry | Typical downstream products | Role of 2,3,4-TFNB |
|---|---|---|
| Pharmaceuticals | Ofloxacin, levofloxacin, benzoxazine intermediates | Starting material |
| Agrochemicals | 2,3,4-Trifluoroaniline derivatives | Building block |
| Fine chemicals | Custom polyfluorinated molecules | Building block |
Safety
Is 2,3,4-Trifluoro Nitro Benzene hazardous?
Yes. 2,3,4-TFNB is harmful if swallowed, in contact with skin or if inhaled, irritates the skin, eyes and respiratory tract, and may cause methaemoglobinaemia at high exposure. With correct PPE, ventilation and storage it is safely handled in industry.
2,3,4-TFNB should be stored in sealed containers in a cool, dry, ventilated place away from heat, strong bases, reducing agents and oxidisers, and handled with gloves, goggles and vapour respiratory protection. Prevent release to drains and waterways. A full MSDS is supplied with every order.
Signal word: Warning
Harmful by ingestion, skin contact and inhalation · irritant · may affect the blood
Safe-handling essentials
- Chemical-resistant gloves, goggles and protective clothing at all times
- Vapour respirator; use local exhaust ventilation
- Avoid skin contact — nitroaromatics are absorbed through the skin
- Keep drums sealed, cool and dry
- Store away from strong bases, reducing agents and oxidisers
- Never allow release to drains, soil or waterways
- Transport as a class 6.1 toxic substance — UN entry stated on the SDS
Grades
2,3,4-Trifluoro Nitro Benzene grades & technical specifications
We supply 2,3,4-TFNB in a high-purity grade with low residual chloro-fluoro content for quinolone synthesis.
| Parameter | Specification |
|---|---|
| Assay (purity) | 99% min |
| Appearance | Clear pale yellow liquid |
| Chloro-difluoro nitrobenzenes | 0.3% max |
| Other isomers | 0.3% max |
| Moisture | 0.1% max |
| Acidity | 0.01% max |
| Density at 25 °C | 1.535 – 1.545 g/mL |
| Product form | Liquid — drums, IBCs |
Note: Values are representative. Batch-specific figures are provided on the Certificate of Analysis (COA) supplied with each consignment.
Supply
Packaging, MOQ & supply
From trial quantities for process validation to repeat container loads on contract — packed, documented and dispatched to your plant in India or overseas.
Packaging
200–250 kg HDPE or MS drums and IBCs, palletised for export.
Minimum order quantity
Flexible — single drums or bags for trials through to full-container loads.
Shelf life
Long shelf life in sealed, unopened drums stored cool, dry and out of direct light.
Dispatch
Pan-India dispatch and worldwide export with complete dangerous-goods documentation and logistics support.
Why buy from us
Why choose Chelora as your 2,3,4-TFNB supplier?
As an established 2,3,4-Trifluoro Nitro Benzene supplier and distributor based in India and shipping worldwide, we work with a wide network of trusted manufacturers to combine consistent quality with dependable service. More about Chelora Agrochem.
High purity, every batch
99% min assay, sourced only from quality-approved manufacturers we have worked with and audited.
Full documentation
COA, MSDS and TDS travel with every order, so your QA and EHS teams are never chasing paperwork.
Reliable bulk supply, flexible MOQ
Single packs for process trials through to repeat container loads on schedule.
Worldwide supply
Export-grade packing, dangerous-goods documentation and on-time dispatch to plants across Asia, the Middle East, Europe, Africa and the Americas.
Technical & safe-handling support
Guidance on storage, PPE and process fit from a team that knows nitroaromatic intermediates.
One point of contact
Source 2,3,4-TFNB alongside your other intermediates — one enquiry, one team, one invoice.
Ordering
How to order 2,3,4-Trifluoro Nitro Benzene from Chelora
Ordering is simple and fast — most enquiries are answered with pricing and availability within 24 hours.
- 1
Send your enquiry
Tell us the grade, quantity and application you are buying for.
- 2
Receive a quotation
We send pricing along with the COA and MSDS for your review.
- 3
Request a sample
Test suitability for your process before you commit to a bulk order.
- 4
Confirm the order
Lock in quantity, packaging and delivery preference.
- 5
Dispatch & tracking
We dispatch with full documentation and keep you updated until delivery.
Documentation
2,3,4-Trifluoro Nitro Benzene MSDS & COA
A summary of key safety information and a representative Certificate of Analysis. The complete 16-section Safety Data Sheet and the actual batch COA are supplied with each shipment — and both are sent with your quotation when you ask for a quote.
Safety data summary (MSDS)
| Section | Details |
|---|---|
| Hazard classification | Acute toxicity cat. 4 (oral / dermal / inhalation); skin, eye and respiratory irritation — further classifications on the SDS |
| Signal word | Warning |
| First aid — inhalation | Move to fresh air; seek medical help. Watch for signs of methaemoglobinaemia (blue lips or nails) |
| First aid — skin | Remove contaminated clothing; wash thoroughly with soap & water |
| First aid — eyes | Rinse with water for several minutes; get medical advice |
| Handling | Use PPE; avoid dust, vapour and skin contact; ventilate |
| Storage | Cool, dry, sealed; away from heat, bases, reducing agents & oxidisers |
| Environment | Prevent release to drains / waterways |
| Transport | Class 6.1; typically UN 2810 — confirm on SDS |
Certificate of Analysis (representative)
| Test parameter | Specification | Method |
|---|---|---|
| Assay (purity) | 99% min | GC |
| Appearance | Clear pale yellow liquid | Visual |
| Chloro-fluoro impurities | 0.3% max | GC |
| Moisture | 0.1% max | Karl Fischer |
| Density at 25 °C | 1.535 – 1.545 g/mL | Density meter |
| Acidity | 0.01% max | Titration |
The actual batch COA is supplied with each shipment.
FAQ
Frequently asked questions
Common questions from buyers specifying 2,3,4-TFNB for fluoroquinolone and fine-chemical production.
What is 2,3,4-Trifluoro Nitro Benzene used for?
2,3,4-TFNB is used mainly as the starting material for the fluoroquinolone antibiotics ofloxacin and levofloxacin. It is also hydrogenated to 2,3,4-trifluoroaniline and used as a polyfluorinated building block in agrochemical and fine-chemical synthesis.
What is the CAS number of 2,3,4-TFNB?
The CAS number is 771-69-7 and the molecular formula is C6H2F3NO2. It is also known as 1,2,3-trifluoro-4-nitrobenzene or 2,3,4-trifluoronitrobenzene.
How is 2,3,4-TFNB made?
2,3,4-Trichloronitrobenzene is heated with anhydrous potassium fluoride in a polar aprotic solvent such as sulfolane. The three chlorines are exchanged for fluorine, and the product is purified by vacuum distillation.
Is 2,3,4-Trifluoro Nitro Benzene hazardous?
Yes. It is harmful if swallowed, in contact with skin or if inhaled, irritates skin, eyes and the respiratory tract, and may cause methaemoglobinaemia at high exposure. Handle it with proper PPE and ventilation; we supply a full MSDS with every order.
Why does residual chloro-fluoro content matter?
Partially fluorinated intermediates from the halogen-exchange step react like the main product and carry chlorine into the antibiotic, where they become hard-to-remove impurities. Keeping them low at the 2,3,4-TFNB stage protects API purity.
How should 2,3,4-TFNB be stored?
In sealed drums in a cool, dry, well-ventilated store, out of direct light and away from heat, strong bases, reducing agents and oxidisers.
Do you provide COA and MSDS for 2,3,4-TFNB?
Yes, we provide a batch-specific COA and MSDS with every order, plus technical support on request.
Do you supply and export 2,3,4-Trifluoro Nitro Benzene?
Yes, we supply 2,3,4-TFNB across India and export internationally with complete dangerous-goods documentation, sourced from reliable manufacturers.
Request a quote or sample
Need a reliable 2,3,4-TFNB supplier?
Looking for a dependable 2,3,4-Trifluoro Nitro Benzene (2,3,4-TFNB) supplier and distributor — in India or anywhere we export to? Tell us the grade and quantity you need — our team responds with competitive bulk pricing, samples and complete documentation (COA, MSDS, TDS) within 24 hours.
Or email source@cheloraagrochem.com