Pharma & agro intermediate
Para Fluoro Aniline (4-Fluoroaniline) Supplier & Distributor in India & Worldwide
Chelora Agrochem is a trusted Para Fluoro Aniline (PFA) supplier and distributor in India, connecting buyers with high-purity material sourced from leading, quality-approved manufacturers. Our 4-Fluoroaniline meets 99% min purity with consistent quality, full documentation and reliable bulk supply across India and to buyers worldwide.
As a specialised distributor of chemical products, we do not manufacture in-house — instead we source only from reliable, audited manufacturers, giving you dependable material, competitive pricing and a single point of contact for all your PFA requirements, backed by COA, MSDS and TDS on every order.
- CAS number
- 371-40-4
- Formula
- C6H6FN
- Molecular weight
- 111.12 g/mol
- Purity
- 99% min
Quick product specifications
Para Fluoro Aniline at a glance
Identifiers, physical data and trade codes for PFA. Batch-specific figures are confirmed on the Certificate of Analysis supplied with each consignment, in India and on export shipments alike.
- Chemical name
- 4-Fluoroaniline
- CAS number
- 371-40-4
- Molecular formula
- C6H6FN
- Molecular weight
- 111.12 g/mol
- IUPAC name
- 4-Fluoroaniline
- HS code
- 2921 42 90
- UN number
- UN 2941Fluoroanilines — class 6.1
- Appearance
- Clear colourless to amber liquidDarkens on exposure to air and light
- Boiling point
- 187–188 °C
- Melting point
- −1.9 °C
- Density
- 1.17 g/mL at 25 °C
- Refractive index
- 1.519 (n20/D)
- Flash point
- ~74 °CClosed cup
- Solubility
- Partly soluble in waterAbout 33 g/L at 20 °C; miscible with common organic solvents
- Purity
- 99% min
- Moisture
- 0.3% max
- Synonyms
- PFAp-Fluoroaniline · 1-Amino-4-fluorobenzene · 4-Fluorobenzenamine
- Product form
- Liquid — drums, IBCs, ISO tanks
- Documentation
- COA, MSDS & TDSSupplied with every order
Product overview
What is Para Fluoro Aniline?
Para Fluoro Aniline (4-fluoroaniline, PFA) is a fluorinated aromatic amine used mainly as a building block in pharmaceutical synthesis — particularly for anti-cancer and anti-inflammatory actives — and in agrochemical and dye manufacture. The para fluorine is carried through the whole synthesis, where it tunes metabolic stability and binding.
With the formula C6H6FN (CAS 371-40-4), PFA is a clear liquid that darkens with air and light. It is produced mainly by catalytic hydrogenation of 4-fluoronitrobenzene, with one-step routes from nitrobenzene also described in the literature.
Because the amino group is free and the fluorine is para to it, PFA acylates, alkylates and condenses cleanly — which is why API and agrochemical producers specify it by assay and colour as closely as by isomer content.
How it is made
The usual two-step route nitrates and fluorinates to 4-fluoronitrobenzene, which is then reduced by catalytic hydrogenation to the aniline. One-step routes from nitrobenzene using reductive fluorination are also documented.
What that means for your process
- Free amino group for acylation, condensation and diazotisation
- Para fluorine retained intact through downstream steps
- Isomer content and aniline residue controlled to grade, checked by GC
- Low moisture and low colour for stable storage and handling
Applications
What is Para Fluoro Aniline used for?
PFA is used as an intermediate in the synthesis of pharmaceuticals, dyes and pesticides. Its main applications, industry by industry, include:
Pharmaceuticals
The main use. PFA is a standard entry point for fluorinated drug scaffolds.
- Key intermediate for anti-cancer and anti-inflammatory actives
- Building block for fluorinated heterocycles and anilides
- Used in API and intermediate custom synthesis
Agrochemicals
Supplies the fluorinated aniline fragment used across modern crop-protection actives.
- Intermediate for selected pesticides
- Supplied to formulators and synthesis units
Dyes & fine chemicals
Diazotised and coupled where a fluorine substituent improves shade and fastness.
- Diazo component for fluorinated dyes
- Reagent and building block in analytical and research work
Process route
How is Para Fluoro Aniline used downstream?
PFA enters a synthesis as the amine. It is acylated or condensed to build an anilide or heterocyclic core, the ring system is elaborated, and the fluorine rides through untouched into the finished active — which is exactly why it is chosen over unsubstituted aniline.
Para Fluoro Aniline
Charged as the fluorinated amine. Assay and colour decide downstream purity.
C6H6FNAcylation or condensation
The amine reacts with an acid chloride, ester or carbonyl partner under controlled conditions.
Acyl / carbonyl partnerRing closure
The intermediate is cyclised into the fluorinated heterocycle or anilide core.
Fluorinated coreFinished active
Purified and finished into the API or crop-protection active, fluorine intact.
API or activeIn depth
Para Fluoro Aniline applications by industry
Below is a detailed breakdown of where PFA is used and the role it plays in each downstream product.
| Industry | Typical downstream products | Role of PFA |
|---|---|---|
| Pharmaceuticals | Anti-cancer and anti-inflammatory actives | Core intermediate |
| Pharmaceuticals | Fluorinated heterocycles and anilides | Building block |
| Agrochemicals | Selected pesticides | Intermediate |
| Dyes | Fluorinated azo dyes | Diazo component |
| Fine chemicals | Custom molecules, analytical reagents | Precursor |
Safety
Is Para Fluoro Aniline hazardous?
Yes. 4-Fluoroaniline is harmful if swallowed, in contact with skin or if inhaled, causes severe skin burns and eye damage, may cause an allergic skin reaction, can damage organs through prolonged or repeated exposure, and is toxic to aquatic life with long-lasting effects. With correct PPE, ventilation and containment it is safely handled in industry.
PFA should be stored in sealed containers in a cool, dark, ventilated place away from acids, acid chlorides, anhydrides, chloroformates and strong oxidisers. It is combustible and darkens with air and light, so nitrogen blanketing is recommended for long storage. Prevent release to drains and waterways. A full MSDS is supplied with every order.
Signal word: Danger
Corrosive to skin and eyes · harmful by all routes · toxic to aquatic life
Safe-handling essentials
- Chemical-resistant gloves, face shield and goggles — the liquid burns skin
- Work with local exhaust ventilation; avoid breathing vapour or mist
- Keep drums sealed, cool and out of direct light
- Blanket with nitrogen for extended storage to limit colour gain
- Store away from acids, acid chlorides, anhydrides and oxidisers
- Never allow release to drains, soil or waterways
- Transport as UN 2941 — a regulated dangerous good
Grades
Para Fluoro Aniline grades & technical specifications
We supply PFA in technical and high-purity grades to match pharmaceutical, agrochemical and fine-chemical requirements.
| Parameter | Specification |
|---|---|
| Assay (purity) | 99% min |
| Appearance | Clear liquid, free from suspended matter |
| Colour | Colourless to amber, as per grade |
| Density at 25 °C | 1.165 – 1.175 g/mL |
| Refractive index (n20/D) | 1.517 – 1.521 |
| Moisture | 0.3% max |
| Isomer purity | As per grade |
| Product form | Liquid — drums, IBCs, ISO tanks |
Note: Values are representative. Batch-specific figures are provided on the Certificate of Analysis (COA) supplied with each consignment.
Supply
Packaging, MOQ & supply
From trial quantities for process validation to repeat tanker loads on contract — packed, documented and dispatched to your plant in India or overseas.
Packaging
200 kg MS or HDPE drums, 1000 L IBCs, ISO tanks or tankers as per grade and quantity.
Minimum order quantity
Flexible — single drums for trials through to full-container and tanker loads.
Shelf life
Long shelf life in sealed, unopened drums stored cool and dark, ideally under nitrogen.
Dispatch
Pan-India dispatch and worldwide export with complete documentation and logistics support.
Why buy from us
Why choose Chelora as your PFA supplier?
As an established Para Fluoro Aniline supplier and distributor based in India and shipping worldwide, we work with a wide network of trusted manufacturers to combine consistent quality with dependable service. More about Chelora Agrochem.
High purity, every batch
99% min assay, sourced only from quality-approved manufacturers we have worked with and audited.
Full documentation
COA, MSDS and TDS travel with every order, so your QA and EHS teams are never chasing paperwork.
Reliable bulk supply, flexible MOQ
Drums for process trials through to repeat tanker loads on schedule.
Worldwide supply
Export-grade packing, documentation and on-time dispatch to plants across Asia, the Middle East, Europe, Africa and the Americas.
Technical & safe-handling support
Guidance on storage, nitrogen blanketing, PPE and process fit from a team that knows aromatic amines.
One point of contact
Source PFA alongside your other intermediates — one enquiry, one team, one invoice.
Ordering
How to order Para Fluoro Aniline from Chelora
Ordering is simple and fast — most enquiries are answered with pricing and availability within 24 hours.
- 1
Send your enquiry
Tell us the grade, quantity and application you are buying for.
- 2
Receive a quotation
We send pricing along with the COA and MSDS for your review.
- 3
Request a sample
Test suitability for your process before you commit to a bulk order.
- 4
Confirm the order
Lock in quantity, packaging and delivery preference.
- 5
Dispatch & tracking
We dispatch with full documentation and keep you updated until delivery.
Documentation
Para Fluoro Aniline MSDS & COA
A summary of key safety information and a representative Certificate of Analysis. The complete 16-section Safety Data Sheet and the actual batch COA are supplied with each shipment — and both are sent with your quotation when you ask for a quote.
Safety data summary (MSDS)
| Section | Details |
|---|---|
| Hazard classification | Harmful (oral / dermal / inhalation); severe skin burns and eye damage; skin sensitiser; organ damage on repeated exposure; toxic to aquatic life |
| Signal word | Danger |
| First aid — inhalation | Move to fresh air; seek medical help |
| First aid — skin | Remove clothing; wash with soap & plenty of water |
| First aid — eyes | Rinse with water for at least 15 minutes; get medical advice |
| Handling | Use PPE; avoid vapour and mist; ventilate |
| Storage | Cool, dark, sealed; away from acids, oxidisers and chloroformates |
| Decomposition | Emits nitrogen oxides, carbon oxides and hydrogen fluoride on burning |
| Environment | Prevent release to drains / waterways |
| Transport | UN 2941; class 6.1; regulated dangerous good |
Certificate of Analysis (representative)
| Test parameter | Specification | Method |
|---|---|---|
| Assay (purity) | 99% min | GC |
| Appearance | Clear liquid | Visual |
| Colour | As per grade | APHA |
| Density at 25 °C | 1.165 – 1.175 g/mL | Density meter |
| Refractive index | 1.517 – 1.521 | Refractometer |
| Moisture | 0.3% max | Karl Fischer |
The actual batch COA is supplied with each shipment.
FAQ
Frequently asked questions
Common questions from buyers specifying Para Fluoro Aniline for pharmaceutical, agrochemical and dye production.
What is Para Fluoro Aniline used for?
PFA is used as an intermediate in the synthesis of pharmaceuticals — notably anti-cancer and anti-inflammatory actives — as well as agrochemicals, dyes and fine chemicals.
What is the CAS number of Para Fluoro Aniline?
The CAS number is 371-40-4 and the molecular formula is C6H6FN. It is also known as PFA, 4-fluoroaniline or 1-amino-4-fluorobenzene.
How is Para Fluoro Aniline manufactured?
Mainly by catalytic hydrogenation of 4-fluoronitrobenzene. One-step routes that reduce and fluorinate nitrobenzene directly are also described in the literature.
Is Para Fluoro Aniline hazardous?
Yes. It is harmful by ingestion, skin contact and inhalation, causes severe skin burns and eye damage, and is toxic to aquatic life. It must be handled with proper PPE, ventilation and containment; we supply a full MSDS with every order.
Why is the fluorine substituent useful?
A para fluorine changes how the finished molecule behaves — it is small, strongly electron-withdrawing and resists metabolism, which is why fluorinated anilines are so common in modern drug and crop-protection molecules.
How should PFA be stored?
In sealed drums or tanks in a cool, dark, well-ventilated store, away from acids, acid chlorides and oxidisers. The liquid darkens with air and light, so a nitrogen blanket is recommended for long holding.
Do you provide COA and MSDS for PFA?
Yes, we provide a batch-specific COA and MSDS with every order, plus technical support on request.
Do you supply and export Para Fluoro Aniline?
Yes, we supply PFA across India and export internationally with complete documentation, sourced from reliable manufacturers.
Request a quote or sample
Need a reliable PFA supplier?
Looking for a dependable Para Fluoro Aniline (4-fluoroaniline) supplier and distributor — in India or anywhere we export to? Tell us the grade and quantity you need — our team responds with competitive bulk pricing, samples and complete documentation (COA, MSDS, TDS) within 24 hours.
Or email source@cheloraagrochem.com