Liquid crystal & fluoro-pharma building block
3,4,5-Trifluoro Bromo Benzene (3,4,5-TFBB) Supplier & Distributor in India & Worldwide
Chelora Agrochem is a trusted 3,4,5-Trifluoro Bromo Benzene (3,4,5-TFBB) supplier and distributor in India, connecting buyers with high-purity material sourced from leading, quality-approved manufacturers. Our 1-bromo-3,4,5-trifluorobenzene meets 99% min GC purity with controlled isomer content, full documentation and reliable supply across India and to buyers worldwide.
As a specialised distributor of chemical products, we do not manufacture in-house — instead we source only from reliable, audited manufacturers, giving you dependable material, competitive pricing and a single point of contact for all your 3,4,5-TFBB requirements, backed by COA, MSDS and TDS on every order.
- CAS number
- 138526-69-9
- Formula
- C6H2BrF3
- Molecular weight
- 210.98 g/mol
- Purity
- 99% min
Quick product specifications
3,4,5-Trifluoro Bromo Benzene at a glance
Identifiers, physical data and trade codes for 3,4,5-TFBB. Batch-specific figures are confirmed on the Certificate of Analysis supplied with each consignment, in India and on export shipments alike.
- Chemical name
- 3,4,5-Trifluoro Bromo Benzene
- CAS number
- 138526-69-9
- Molecular formula
- C6H2BrF3
- Molecular weight
- 210.98 g/mol
- IUPAC name
- 1-Bromo-3,4,5-trifluorobenzene
- EC number
- Not assigned
- HS code
- 2903 99National subheading as per destination
- UN number
- UN 1993Flammable liquid, n.o.s. · Class 3, PG III. The classification on your shipping documents applies
- Appearance
- Clear colourless to pale yellow liquidSupplied under nitrogen in lined or steel drums
- Melting point
- Below −20 °C
- Boiling point
- 150–152 °C
- Density
- About 1.77 g/cm³Liquid, 25 °C; refractive index about 1.48 at 20 °C
- Flash point
- About 45 °CClosed cup — flammable liquid, category 3
- Solubility
- Practically insoluble in waterMiscible with THF, toluene, ethers and most common organic solvents
- Purity
- 99% min
- Synonyms
- 3,4,5-TFBB1-Bromo-3,4,5-trifluorobenzene · 5-Bromo-1,2,3-trifluorobenzene
- Product form
- Bulk liquid
- Documentation
- COA, MSDS & TDSSupplied with every order
Product overview
What is 3,4,5-Trifluoro Bromo Benzene?
3,4,5-Trifluoro Bromo Benzene (3,4,5-TFBB) is a fluorinated aryl bromide used as a coupling partner in the synthesis of liquid crystal materials, fluorinated pharmaceutical intermediates and agrochemical actives. The bromine is the reactive handle; the three fluorines are what the finished molecule is bought for.
With the formula C6H2BrF3 (CAS 138526-69-9), 3,4,5-TFBB is a clear colourless to pale yellow liquid that boils at about 151 °C, stays liquid well below −20 °C and is practically insoluble in water while mixing freely with THF, toluene and ethers. It is appreciably denser than water, at roughly 1.77 g/cm³.
The 3,4,5-trifluorophenyl group is one of the signature terminal units in modern TFT display materials, because the fluorines give the strong negative dielectric anisotropy and low viscosity those mixtures need. In pharmaceutical work the same unit is used to block metabolism and tune lipophilicity, so demand for this building block runs across both industries.
How it is made
3,4,5-TFBB is produced either by the directed bromination of 1,2,3-trifluorobenzene or by diazotisation of 3,4,5-trifluoroaniline followed by Sandmeyer bromination. The crude product is washed, dried and purified by fractional distillation under reduced pressure, then packed under nitrogen.
What that means for your process
- 99% min GC purity for reproducible coupling yields
- Controlled isomeric bromotrifluorobenzene and dibromo content
- Low moisture — important for Grignard and lithiation steps
- Nitrogen-blanketed packing to preserve colour and purity
Applications
What is 3,4,5-Trifluoro Bromo Benzene used for?
3,4,5-TFBB is used as a building block rather than as a finished product. Its main applications, industry by industry, include:
Liquid crystal materials
The classic terminal unit for negative-dielectric TFT-LCD mixtures.
- Suzuki coupling to trifluorinated biphenyls and terphenyls
- Grignard routes to fluorinated LC cores
- Display-grade purity for mixture formulation
Pharmaceutical intermediates
A fluoroaromatic handle used to block metabolism and tune lipophilicity.
- Cross-coupling to trifluorophenyl API fragments
- Halogen-metal exchange and carboxylation
- Fluorinated boronic acids and esters
Agrochemicals & electronic materials
Fluorinated aryl groups for crop-protection actives and organic electronics.
- Trifluorophenyl crop-protection intermediates
- OLED and electronic material building blocks
- Custom fluoroaromatic synthesis
Process route
How is 3,4,5-TFBB used to build liquid crystal materials?
The chemistry is cross-coupling. The carbon–bromine bond is converted into a carbon–metal bond, or coupled directly with a boronic acid, so the 3,4,5-trifluorophenyl unit can be joined to a cyclohexyl or biphenyl core. The fluorines are untouched throughout, which is exactly why the bromide is the preferred starting point.
3,4,5-Trifluoro Bromo Benzene
Charged dry under nitrogen. GC purity and moisture decide coupling conversion.
C6H2BrF3Metalation or coupling
Converted to the Grignard or boronic acid, or coupled directly under palladium catalysis.
Mg / Pd catalystTrifluorophenyl core
The 3,4,5-trifluorophenyl unit is joined to a cyclohexyl or biphenyl ring system.
Biphenyl coreLC or API material
Purified to display grade for mixture formulation, or carried on as an API fragment.
TFT-LCD mixtureIn depth
3,4,5-Trifluoro Bromo Benzene applications by industry
Below is a detailed breakdown of where 3,4,5-TFBB is used and the role it plays in each downstream product.
| Industry | Typical downstream products | Role of 3,4,5-TFBB |
|---|---|---|
| Display materials | Negative-dielectric TFT-LCD liquid crystals | Core building block |
| Pharmaceuticals | Trifluorophenyl API fragments, fluoro-boronic acids | Intermediate |
| Agrochemicals | Fluorinated crop-protection actives | Intermediate |
| Electronic materials | OLED and organic semiconductor building blocks | Building block |
| Fine chemicals | Custom fluoroaromatic synthesis | Building block |
Safety
Is 3,4,5-Trifluoro Bromo Benzene hazardous?
Yes. 3,4,5-TFBB is a flammable liquid with a flash point around 45 °C, causes skin irritation and serious eye damage, may cause respiratory irritation, is suspected of causing cancer, and is toxic to aquatic life with long-lasting effects.
3,4,5-TFBB should be stored in sealed, bunded drums in a cool, dry, ventilated place under nitrogen, away from heat, open flames, static discharge and strong oxidisers, and handled with chemical-resistant gloves, goggles or a face shield and protective clothing, under local exhaust ventilation or in a closed transfer system. Because it is a suspected carcinogen, exposure should be engineered out rather than managed with PPE alone. A full MSDS is supplied with every order.
Signal word: Danger
Flammable liquid and vapour · causes serious eye damage and skin irritation · suspected of causing cancer · toxic to aquatic life with long-lasting effects
Safe-handling essentials
- Closed transfer or local exhaust ventilation — engineer exposure out
- Chemical-resistant gloves, goggles or face shield and protective clothing
- Keep away from open flames, hot surfaces and other ignition sources
- Earth and bond containers during transfer; control static
- Keep drums sealed and nitrogen-blanketed; store cool and dry
- Store away from strong oxidisers and strong bases
- Bund storage and never allow release to drains, soil or waterways
- Transport as UN 1993, class 3, packing group III
Grades
3,4,5-Trifluoro Bromo Benzene grades & technical specifications
We supply 3,4,5-TFBB in standard synthesis grade and in high-purity, low-moisture grades for display and pharmaceutical work.
| Parameter | Specification |
|---|---|
| Assay (GC purity) | 99% min |
| Appearance | Clear colourless to pale yellow liquid |
| Isomeric bromotrifluorobenzenes | 0.5% max |
| Dibromotrifluorobenzenes | 0.3% max |
| 1,2,3-Trifluorobenzene | 0.3% max |
| Colour (APHA / Hazen) | 50 max |
| Moisture | 0.05% max |
| Refractive index (20 °C) | 1.478–1.482 |
Note: Values are representative. Batch-specific figures are provided on the Certificate of Analysis (COA) supplied with each consignment.
Supply
Packaging, MOQ & supply
From trial quantities for process validation to repeat container loads on contract — packed, documented and dispatched to your plant in India or overseas.
Packaging
25 kg and 50 kg HDPE or lined steel drums and 250 kg drums, blanketed with nitrogen; smaller packs for development work on request.
Minimum order quantity
Flexible — kilogram development packs through to drum and pallet quantities.
Shelf life
Good shelf life in sealed, unopened drums stored cool, dry, under nitrogen and away from ignition sources.
Dispatch
Pan-India dispatch and worldwide export with complete dangerous-goods documentation and logistics support.
Why buy from us
Why choose Chelora as your 3,4,5-TFBB supplier?
As an established 3,4,5-Trifluoro Bromo Benzene supplier and distributor based in India and shipping worldwide, we work with a wide network of trusted manufacturers to combine consistent quality with dependable service. More about Chelora Agrochem.
High purity, every batch
99% min assay, sourced only from quality-approved manufacturers we have worked with and audited.
Full documentation
COA, MSDS and TDS travel with every order, so your QA and EHS teams are never chasing paperwork.
Reliable bulk supply, flexible MOQ
Single packs for process trials through to repeat container loads on schedule.
Worldwide supply
Export-grade packing, dangerous-goods documentation and on-time dispatch to plants across Asia, the Middle East, Europe, Africa and the Americas.
Technical & safe-handling support
Guidance on storage, inerting, PPE and process fit from a team that knows fluoroaromatic building blocks.
One point of contact
Source 3,4,5-TFBB alongside your other intermediates — one enquiry, one team, one invoice.
Ordering
How to order 3,4,5-Trifluoro Bromo Benzene from Chelora
Ordering is simple and fast — most enquiries are answered with pricing and availability within 24 hours.
- 1
Send your enquiry
Tell us the grade, quantity and application you are buying for.
- 2
Receive a quotation
We send pricing along with the COA and MSDS for your review.
- 3
Request a sample
Test suitability for your process before you commit to a bulk order.
- 4
Confirm the order
Lock in quantity, packaging and delivery preference.
- 5
Dispatch & tracking
We dispatch with full documentation and keep you updated until delivery.
Documentation
3,4,5-Trifluoro Bromo Benzene MSDS & COA
A summary of key safety information and a representative Certificate of Analysis. The complete 16-section Safety Data Sheet and the actual batch COA are supplied with each shipment — and both are sent with your quotation when you ask for a quote.
Safety data summary (MSDS)
| Section | Details |
|---|---|
| Hazard classification | Flammable liquid cat. 3; skin irritation cat. 2; serious eye damage cat. 1; STOT SE cat. 3 (respiratory irritation); carcinogenicity cat. 2; aquatic chronic cat. 2 |
| Signal word | Danger |
| First aid — inhalation | Move to fresh air; keep at rest; get medical attention |
| First aid — skin | Remove contaminated clothing; wash thoroughly with soap & water |
| First aid — eyes | Rinse cautiously with water for several minutes; get immediate medical attention |
| Handling | Closed transfer or local exhaust; full PPE; control ignition sources and static |
| Storage | Cool, dry, sealed, nitrogen-blanketed and bunded; away from heat & oxidisers |
| Environment | Toxic to aquatic life with long-lasting effects; prevent release to drains / waterways |
| Transport | UN 1993; class 3; packing group III |
Certificate of Analysis (representative)
| Test parameter | Specification | Method |
|---|---|---|
| Assay (GC purity) | 99% min | GC |
| Appearance | Clear colourless to pale yellow liquid | Visual |
| Isomeric impurities | 0.5% max | GC |
| Colour (APHA) | 50 max | Comparator |
| Refractive index (20 °C) | 1.478–1.482 | Refractometer |
| Moisture | 0.05% max | Karl Fischer |
The actual batch COA is supplied with each shipment.
FAQ
Frequently asked questions
Common questions from buyers specifying 3,4,5-TFBB for display materials, pharmaceutical and agrochemical synthesis.
What is 3,4,5-Trifluoro Bromo Benzene used for?
3,4,5-TFBB is used mainly as a cross-coupling building block for liquid crystal materials used in TFT-LCD displays, for fluorinated pharmaceutical intermediates, for agrochemical actives carrying a trifluorophenyl group, and for OLED and other electronic materials.
What is the CAS number of 3,4,5-TFBB?
The CAS number is 138526-69-9 and the molecular formula is C6H2BrF3, with a molecular weight of 210.98 g/mol. The IUPAC name is 1-bromo-3,4,5-trifluorobenzene; it is also listed as 5-bromo-1,2,3-trifluorobenzene.
How is 3,4,5-Trifluoro Bromo Benzene made?
It is produced either by the directed bromination of 1,2,3-trifluorobenzene or by diazotisation of 3,4,5-trifluoroaniline followed by Sandmeyer bromination, then purified by fractional distillation under reduced pressure and packed under nitrogen.
Is 3,4,5-Trifluoro Bromo Benzene hazardous?
Yes. It is a flammable liquid, causes skin irritation and serious eye damage, may cause respiratory irritation, is suspected of causing cancer, and is toxic to aquatic life with long-lasting effects. Use closed transfer or local exhaust ventilation, full PPE and bunded storage; we supply a full MSDS with every order.
Why is the trifluorophenyl group used in liquid crystals and drugs?
In display mixtures the three fluorines give the strong negative dielectric anisotropy and low rotational viscosity that fast-switching TFT panels need. In medicinal chemistry the same fluorines block metabolic oxidation of the ring and raise lipophilicity, which can improve a molecule's half-life and membrane permeability.
How should 3,4,5-TFBB be stored?
In sealed drums under a nitrogen blanket, in a cool, dry, well-ventilated and bunded store away from heat, open flames, static discharge and strong oxidisers. Keep moisture out, since downstream Grignard and lithiation steps are sensitive to it.
Do you provide COA and MSDS for 3,4,5-TFBB?
Yes, we provide a batch-specific COA and MSDS with every order, plus technical support on request.
Do you supply and export 3,4,5-Trifluoro Bromo Benzene?
Yes, we supply 3,4,5-TFBB across India and export internationally with complete dangerous-goods documentation, sourced from reliable manufacturers.
Request a quote or sample
Need a reliable 3,4,5-TFBB supplier?
Looking for a dependable 3,4,5-Trifluoro Bromo Benzene (3,4,5-TFBB) supplier and distributor — in India or anywhere we export to? Tell us the grade and quantity you need — our team responds with competitive bulk pricing, samples and complete documentation (COA, MSDS, TDS) within 24 hours.
Or email source@cheloraagrochem.com