Fluoro-aromatic intermediate
Para Fluoro Nitro Benzene (PFNB) Supplier & Distributor in India & Worldwide
Chelora Agrochem is a trusted Para Fluoro Nitro Benzene (PFNB) supplier and distributor in India, connecting buyers with high-purity material sourced from leading, quality-approved manufacturers. Our 1-fluoro-4-nitrobenzene meets 99.5% min purity with low residual PNCB, full documentation and reliable bulk supply across India and to buyers worldwide.
As a specialised distributor of chemical products, we do not manufacture in-house — instead we source only from reliable, audited manufacturers, giving you dependable material, competitive pricing and a single point of contact for all your PFNB requirements, backed by COA, MSDS and TDS on every order.
- CAS number
- 350-46-9
- Formula
- C6H4FNO2
- Molecular weight
- 141.10 g/mol
- Purity
- 99.5% min
Quick product specifications
Para Fluoro Nitro Benzene at a glance
Identifiers, physical data and trade codes for PFNB. Batch-specific figures are confirmed on the Certificate of Analysis supplied with each consignment, in India and on export shipments alike.
- Chemical name
- Para Fluoro Nitro Benzene
- CAS number
- 350-46-9
- Molecular formula
- C6H4FNO2
- Molecular weight
- 141.10 g/mol
- IUPAC name
- 1-Fluoro-4-nitrobenzene
- EC number
- 206-503-0
- HS code
- 2904 99National subheading as per destination
- UN number
- Typically UN 2810 (liquid) or UN 2811 (solid)Toxic, organic, n.o.s. · Class 6.1 — confirm on SDS
- Appearance
- Pale yellow liquid or low-melting solidSolidifies below about 21 °C
- Melting point
- 21–24 °C
- Boiling point
- 205 °C
- Density
- About 1.33 g/mLAt 25 °C
- Flash point
- About 83 °CClosed cup, combustible liquid
- Solubility
- Practically insoluble in waterMiscible with common organic solvents
- Purity
- 99.5% min
- Synonyms
- PFNB4-Fluoronitrobenzene · p-Nitrofluorobenzene · 4-Nitrofluorobenzene
- Product form
- Liquid or solid — drums, IBCs
- Documentation
- COA, MSDS & TDSSupplied with every order
Product overview
What is Para Fluoro Nitro Benzene?
Para Fluoro Nitro Benzene (PFNB) is a fluorinated nitroaromatic used mainly as the precursor of 4-fluoroaniline and as an activated aryl fluoride for nucleophilic substitution. The fluorine opposite the nitro group is displaced readily by amines, phenols and thiols.
With the formula C6H4FNO2 (CAS 350-46-9), PFNB is a pale yellow liquid that solidifies at about 21–24 °C and is practically insoluble in water. It is made from PNCB by halogen exchange with potassium fluoride.
Because fluoride is an excellent leaving group when activated by a para-nitro group, PFNB reacts faster and more cleanly than PNCB in substitution reactions — which is why pharmaceutical customers specify residual PNCB as closely as assay.
How it is made
PNCB is heated with anhydrous potassium fluoride in a polar aprotic solvent such as sulfolane or DMSO, often with a phase-transfer catalyst. The chlorine is exchanged for fluorine, and PFNB is purified by distillation.
What that means for your process
- Highly activated fluorine for fast substitution
- Low residual PNCB, checked by GC
- Low moisture for anhydrous reactions
- Liquid or solid supply to suit your charging system
Applications
What is Para Fluoro Nitro Benzene used for?
PFNB is used almost entirely as a chemical intermediate. Its main applications, industry by industry, include:
Pharmaceuticals
Reduced to 4-fluoroaniline, or used directly to attach a 4-nitrophenyl group to amines and phenols.
- 4-Fluoroaniline for API synthesis
- 4-Nitrophenyl piperazines and ethers by substitution
- Fluorinated building blocks for drug discovery
Agrochemicals
4-Fluoroaniline from PFNB is the aniline building block for several crop-protection actives.
- Precursor of 4-fluoroaniline
- Route to the N-(4-fluorophenyl) amide herbicide flufenacet
- Fluorinated fungicide and insecticide intermediates
Dyes, polymers & fine chemicals
Used in dye intermediates, high-performance polymer monomers and custom synthesis.
- Nitrodiphenyl ether and amine intermediates
- Custom synthesis and research scale-up
Process route
How is PFNB used to make 4-fluoroaniline?
PFNB is reduced to 4-fluoroaniline by catalytic hydrogenation. 4-Fluoroaniline is then built into pharmaceutical and agrochemical actives — for example by N-alkylation and acylation to give the herbicide flufenacet.
Para Fluoro Nitro Benzene
Charged as the nitro compound. Assay and residual PNCB decide aniline purity.
C6H4FNO2Catalytic hydrogenation
Reduced with hydrogen over a catalyst under conditions that preserve the C–F bond.
H2 / catalyst4-Fluoroaniline
The fluorinated aniline, alkylated or acylated in the next step.
4-FAActive ingredient
Pharmaceutical APIs and agrochemicals such as flufenacet.
FlufenacetIn depth
Para Fluoro Nitro Benzene applications by industry
Below is a detailed breakdown of where PFNB is used and the role it plays in each downstream product.
| Industry | Typical downstream products | Role of PFNB |
|---|---|---|
| Pharmaceuticals | 4-Fluoroaniline-based APIs, 4-nitrophenyl piperazines | Precursor / building block |
| Agrochemicals | Flufenacet and fluorinated actives | Precursor via 4-fluoroaniline |
| Dyes | Fluorinated dye intermediates | Intermediate |
| Polymers | Fluoro-aromatic monomers | Building block |
| Fine chemicals | Custom fluorinated molecules | Building block |
Safety
Is Para Fluoro Nitro Benzene hazardous?
Yes. PFNB is toxic if inhaled, harmful if swallowed or in contact with skin, and may cause damage to the blood through repeated exposure by causing methaemoglobinaemia. It is also harmful to aquatic life. With correct PPE, ventilation and storage it is safely handled in industry.
PFNB should be stored in sealed containers in a cool, dry, ventilated place away from heat, strong bases, reducing agents and oxidisers, and handled with gloves, goggles and vapour respiratory protection. Prevent release to drains and waterways. A full MSDS is supplied with every order.
Signal word: Danger
Toxic if inhaled · harmful by ingestion and skin contact · may affect the blood
Safe-handling essentials
- Chemical-resistant gloves, goggles and protective clothing at all times
- Vapour respirator; use local exhaust ventilation
- Avoid skin contact — PFNB is absorbed through the skin
- Keep drums sealed, cool and dry
- Store away from strong bases, reducing agents and oxidisers
- Never allow release to drains, soil or waterways
- Transport as a class 6.1 toxic substance — UN entry stated on the SDS
Grades
Para Fluoro Nitro Benzene grades & technical specifications
We supply PFNB in standard and pharmaceutical-intermediate grades with low residual PNCB.
| Parameter | Specification |
|---|---|
| Assay (purity) | 99.5% min |
| Appearance | Pale yellow liquid or solid |
| Para-nitrochlorobenzene | 0.2% max |
| Ortho-fluoronitrobenzene | 0.1% max |
| Freezing point | 21 °C min |
| Moisture | 0.1% max |
| Density at 25 °C | 1.325 – 1.335 g/mL |
| Product form | Liquid or solid — drums, IBCs |
Note: Values are representative. Batch-specific figures are provided on the Certificate of Analysis (COA) supplied with each consignment.
Supply
Packaging, MOQ & supply
From trial quantities for process validation to repeat container loads on contract — packed, documented and dispatched to your plant in India or overseas.
Packaging
200–250 kg HDPE or MS drums and IBCs; heated storage keeps PFNB liquid for easy pumping.
Minimum order quantity
Flexible — single drums or bags for trials through to full-container loads.
Shelf life
Long shelf life in sealed, unopened drums stored cool, dry and out of direct light.
Dispatch
Pan-India dispatch and worldwide export with complete dangerous-goods documentation and logistics support.
Why buy from us
Why choose Chelora as your PFNB supplier?
As an established Para Fluoro Nitro Benzene supplier and distributor based in India and shipping worldwide, we work with a wide network of trusted manufacturers to combine consistent quality with dependable service. More about Chelora Agrochem.
High purity, every batch
99.5% min assay, sourced only from quality-approved manufacturers we have worked with and audited.
Full documentation
COA, MSDS and TDS travel with every order, so your QA and EHS teams are never chasing paperwork.
Reliable bulk supply, flexible MOQ
Single packs for process trials through to repeat container loads on schedule.
Worldwide supply
Export-grade packing, dangerous-goods documentation and on-time dispatch to plants across Asia, the Middle East, Europe, Africa and the Americas.
Technical & safe-handling support
Guidance on storage, PPE and process fit from a team that knows nitroaromatic intermediates.
One point of contact
Source PFNB alongside your other intermediates — one enquiry, one team, one invoice.
Ordering
How to order Para Fluoro Nitro Benzene from Chelora
Ordering is simple and fast — most enquiries are answered with pricing and availability within 24 hours.
- 1
Send your enquiry
Tell us the grade, quantity and application you are buying for.
- 2
Receive a quotation
We send pricing along with the COA and MSDS for your review.
- 3
Request a sample
Test suitability for your process before you commit to a bulk order.
- 4
Confirm the order
Lock in quantity, packaging and delivery preference.
- 5
Dispatch & tracking
We dispatch with full documentation and keep you updated until delivery.
Documentation
Para Fluoro Nitro Benzene MSDS & COA
A summary of key safety information and a representative Certificate of Analysis. The complete 16-section Safety Data Sheet and the actual batch COA are supplied with each shipment — and both are sent with your quotation when you ask for a quote.
Safety data summary (MSDS)
| Section | Details |
|---|---|
| Hazard classification | Acute toxicity cat. 3 (inhalation), cat. 4 (oral / dermal); STOT RE cat. 2 (blood) — further classifications on the SDS |
| Signal word | Danger |
| First aid — inhalation | Move to fresh air; seek medical help. Watch for signs of methaemoglobinaemia (blue lips or nails) |
| First aid — skin | Remove contaminated clothing; wash thoroughly with soap & water |
| First aid — eyes | Rinse with water for several minutes; get medical advice |
| Handling | Use PPE; avoid dust, vapour and skin contact; ventilate |
| Storage | Cool, dry, sealed; away from heat, bases, reducing agents & oxidisers |
| Environment | Harmful to aquatic life; prevent release to drains / waterways |
| Transport | Class 6.1; typically UN 2810 or UN 2811 — confirm on SDS |
Certificate of Analysis (representative)
| Test parameter | Specification | Method |
|---|---|---|
| Assay (purity) | 99.5% min | GC |
| Appearance | Pale yellow liquid | Visual |
| PNCB | 0.2% max | GC |
| Freezing point | 21 °C min | Cooling curve |
| Density at 25 °C | 1.325 – 1.335 g/mL | Density meter |
| Moisture | 0.1% max | Karl Fischer |
The actual batch COA is supplied with each shipment.
FAQ
Frequently asked questions
Common questions from buyers specifying PFNB for pharmaceutical, agrochemical and fine-chemical production.
What is Para Fluoro Nitro Benzene used for?
PFNB is used mainly to make 4-fluoroaniline for pharmaceuticals and agrochemicals such as flufenacet, and as an activated aryl fluoride for attaching a 4-nitrophenyl group to amines, phenols and thiols. It is also used in dye, polymer and fine-chemical intermediates.
What is the CAS number of PFNB?
The CAS number is 350-46-9 and the molecular formula is C6H4FNO2. It is also known as 1-fluoro-4-nitrobenzene, 4-fluoronitrobenzene or p-nitrofluorobenzene.
How is PFNB made?
PNCB is heated with anhydrous potassium fluoride in a polar aprotic solvent such as sulfolane or DMSO. The chlorine is exchanged for fluorine, and PFNB is purified by distillation.
Is Para Fluoro Nitro Benzene hazardous?
Yes. It is toxic if inhaled, harmful if swallowed or in contact with skin, and may cause methaemoglobinaemia through repeated exposure. Handle it with full PPE, ventilation and containment; we supply a full MSDS with every order.
Why is PFNB solid in winter?
PFNB melts at about 21–24 °C, so it can solidify in cool stores. This does not harm the product. Warm the closed drum gently and evenly, or store it in a heated area, before pumping.
How should PFNB be stored?
In sealed drums in a cool, dry, well-ventilated store, out of direct light and away from heat, strong bases, reducing agents and oxidisers.
Do you provide COA and MSDS for PFNB?
Yes, we provide a batch-specific COA and MSDS with every order, plus technical support on request.
Do you supply and export Para Fluoro Nitro Benzene?
Yes, we supply PFNB across India and export internationally with complete dangerous-goods documentation, sourced from reliable manufacturers.
Request a quote or sample
Need a reliable PFNB supplier?
Looking for a dependable Para Fluoro Nitro Benzene (PFNB) supplier and distributor — in India or anywhere we export to? Tell us the grade and quantity you need — our team responds with competitive bulk pricing, samples and complete documentation (COA, MSDS, TDS) within 24 hours.
Or email source@cheloraagrochem.com