Pharma & agrochemical building block
2-Bromo-4-Fluoro Acetanilide (2-B-4-FAA) Supplier & Distributor in India & Worldwide
Chelora Agrochem is a trusted 2-Bromo-4-Fluoro Acetanilide (2-B-4-FAA) supplier and distributor in India, connecting buyers with high-purity material sourced from leading, quality-approved manufacturers. Our N-(2-bromo-4-fluorophenyl)acetamide meets 98% min purity with a tight melting range, full documentation and reliable supply across India and to buyers worldwide.
As a specialised distributor of chemical products, we do not manufacture in-house — instead we source only from reliable, audited manufacturers, giving you dependable material, competitive pricing and a single point of contact for all your 2-B-4-FAA requirements, backed by COA, MSDS and TDS on every order.
- CAS number
- 1009-22-9
- Formula
- C8H7BrFNO
- Molecular weight
- 232.05 g/mol
- Purity
- 98% min
Quick product specifications
2-Bromo-4-Fluoro Acetanilide at a glance
Identifiers, physical data and trade codes for 2-B-4-FAA. Batch-specific figures are confirmed on the Certificate of Analysis supplied with each consignment, in India and on export shipments alike.
- Chemical name
- 2-Bromo-4-Fluoro Acetanilide
- CAS number
- 1009-22-9
- Molecular formula
- C8H7BrFNO
- Molecular weight
- 232.05 g/mol
- IUPAC name
- N-(2-Bromo-4-fluorophenyl)acetamide
- EC number
- 600-141-3
- HS code
- 2924 29National subheading as per destination
- UN number
- Per supplier SDSNo UN number is normally assigned to this product; the classification stated on the supplier Safety Data Sheet and the shipping documents for your consignment applies
- Appearance
- White to off-white crystalline powderFree-flowing; sharp melting range is the usual identity check
- Melting point
- 117–119 °C
- Boiling point
- About 337 °C
- Density
- About 1.6 g/cm³Calculated value for the solid
- Flash point
- Not establishedCombustible solid — keep away from ignition sources
- Solubility
- Practically insoluble in waterSoluble in methanol, dichloromethane, DMF and hot ethanol
- Purity
- 98% min
- Synonyms
- 2-B-4-FAA2'-Bromo-4'-fluoroacetanilide · N-(2-Bromo-4-fluorophenyl)acetamide
- Product form
- Crystalline powder
- Documentation
- COA, MSDS & TDSSupplied with every order
Product overview
What is 2-Bromo-4-Fluoro Acetanilide?
2-Bromo-4-Fluoro Acetanilide (2-B-4-FAA) is a protected halogenated aniline — an acetyl-capped 2-bromo-4-fluoroaniline. The acetyl group keeps the amine out of the way so the carbon–bromine bond can be used selectively in metalation and cross-coupling, and is removed by hydrolysis once that work is done.
With the formula C8H7BrFNO (CAS 1009-22-9), 2-B-4-FAA is a white to off-white crystalline powder melting sharply at 117–119 °C. It is practically insoluble in water but dissolves readily in methanol, dichloromethane and DMF, which are the solvents most of its downstream chemistry is run in.
It is made by acetylating 4-fluoroaniline and then brominating the resulting anilide, where the acetamido group directs the incoming bromine cleanly to the adjacent position. That regiochemistry is the whole point of the molecule: brominating the free aniline gives a much less selective result.
How it is made
4-Fluoroaniline is acetylated with acetic anhydride to 4-fluoroacetanilide, then brominated with bromine or N-bromosuccinimide under controlled temperature. The acetamido group directs substitution to the position next to it, and the product is isolated by crystallisation, washed and dried to a tight melting range.
What that means for your process
- Sharp 117–119 °C melting range as the primary identity and purity check
- Low isomeric bromo content and low unreacted 4-fluoroacetanilide
- Low moisture and low residual solvent for coupling chemistry
- Free-flowing crystalline powder for clean charging
Applications
What is 2-Bromo-4-Fluoro Acetanilide used for?
2-B-4-FAA is used as a protected building block rather than as a finished product. Its main applications, industry by industry, include:
Pharmaceutical intermediates
A selectively functionalised aniline for fluorinated heterocycle synthesis.
- Palladium cross-coupling at the carbon–bromine bond
- Halogen–metal exchange and quenching with electrophiles
- Hydrolysis to 2-bromo-4-fluoroaniline when the free amine is wanted
Fluorinated heterocycles
The bromo and amino groups together close onto five- and six-membered rings.
- Indoles and indazoles by Larock-type annulation
- Benzimidazoles and benzothiazoles
- Quinazolines and fused nitrogen heterocycles
Agrochemicals & fine chemicals
Fluorinated anilide motifs used across crop-protection chemistry.
- Fluoroaniline-derived amides and ureas
- Halogenated anilide intermediates
- Custom protected aniline synthesis
Process route
How is 2-B-4-FAA used to build fluorinated heterocycles?
The sequence is protect, couple, deprotect, cyclise. The acetyl group arrives already in place, the bromine is consumed in a coupling or metalation step, the acetamide is then hydrolysed back to the free amine, and that amine closes the ring onto whatever was installed at the bromine position.
2-Bromo-4-Fluoro Acetanilide
Charged dry. Melting range and isomer purity decide coupling selectivity.
C8H7BrFNOCoupling at C–Br
Sonogashira, Suzuki or Heck coupling, or halogen–metal exchange, at the bromine.
Pd catalystDeprotection
The acetamide is hydrolysed under acid or base to reveal the free aniline.
HydrolysisFluorinated heterocycle
The amine cyclises onto the newly installed group to give the indole, benzimidazole or quinazoline.
HeterocycleIn depth
2-Bromo-4-Fluoro Acetanilide applications by industry
Below is a detailed breakdown of where 2-B-4-FAA is used and the role it plays in each downstream product.
| Industry | Typical downstream products | Role of 2-B-4-FAA |
|---|---|---|
| Pharmaceuticals | Fluorinated indoles, benzimidazoles, quinazolines | Core building block |
| Agrochemicals | Fluoroanilide amides and ureas | Intermediate |
| Fine chemicals | 2-Bromo-4-fluoroaniline and its derivatives | Protected precursor |
| Contract research | Route scouting for fluorinated scaffolds | Building block |
| Specialty materials | Halogenated anilide monomers and ligands | Building block |
Safety
Is 2-Bromo-4-Fluoro Acetanilide hazardous?
Yes. 2-B-4-FAA is harmful if swallowed, in contact with skin or if inhaled, and it irritates the eyes, skin and respiratory tract. It is a combustible solid for which no flash point has been established, so ignition sources should be controlled as a matter of course.
2-B-4-FAA should be stored in sealed drums in a cool, dry, ventilated place away from heat, light, strong oxidisers and strong bases, and handled with chemical-resistant gloves, goggles and protective clothing, with local exhaust ventilation or dust extraction at the charging point. As a fine crystalline powder it raises dust readily, so dust control is the main day-to-day exposure measure. A full MSDS is supplied with every order.
Signal word: Warning
Harmful if swallowed, in contact with skin or if inhaled · irritating to eyes, skin and respiratory system
Safe-handling essentials
- Chemical-resistant gloves, goggles and protective clothing
- Dust extraction or local exhaust ventilation at the charging point
- Avoid raising dust when weighing and transferring
- Avoid prolonged or repeated skin contact
- Keep drums sealed, cool, dry and out of direct light
- Store away from strong oxidisers and strong bases
- Prevent release to drains, soil and waterways
- Confirm the transport classification on the SDS before despatch
Grades
2-Bromo-4-Fluoro Acetanilide grades & technical specifications
We supply 2-B-4-FAA in standard synthesis grade and in high-purity grades with tightened isomer and residual solvent limits for regulated pharmaceutical work.
| Parameter | Specification |
|---|---|
| Assay (purity) | 98% min |
| Appearance | White to off-white crystalline powder |
| Melting range | 117–119 °C |
| Isomeric bromo compounds | 0.5% max |
| 4-Fluoroacetanilide (unreacted) | 0.5% max |
| Moisture | 0.5% max |
| Residue on ignition | 0.1% max |
| Product form | Crystalline powder |
Note: Values are representative. Batch-specific figures are provided on the Certificate of Analysis (COA) supplied with each consignment.
Supply
Packaging, MOQ & supply
From trial quantities for process validation to repeat container loads on contract — packed, documented and dispatched to your plant in India or overseas.
Packaging
25 kg fibre or HDPE drums with inner liners, and 50 kg drums for bulk users; 1 kg and 5 kg laboratory packs for development work.
Minimum order quantity
Flexible — laboratory packs for route scouting through to drum and pallet quantities.
Shelf life
Long shelf life in sealed, unopened drums stored cool, dry and away from light.
Dispatch
Pan-India dispatch and worldwide export with complete dangerous-goods documentation and logistics support.
Why buy from us
Why choose Chelora as your 2-B-4-FAA supplier?
As an established 2-Bromo-4-Fluoro Acetanilide supplier and distributor based in India and shipping worldwide, we work with a wide network of trusted manufacturers to combine consistent quality with dependable service. More about Chelora Agrochem.
High purity, every batch
98% min assay, sourced only from quality-approved manufacturers we have worked with and audited.
Full documentation
COA, MSDS and TDS travel with every order, so your QA and EHS teams are never chasing paperwork.
Reliable bulk supply, flexible MOQ
Single packs for process trials through to repeat container loads on schedule.
Worldwide supply
Export-grade packing, dangerous-goods documentation and on-time dispatch to plants across Asia, the Middle East, Europe, Africa and the Americas.
Technical & safe-handling support
Guidance on storage, PPE, deprotection conditions and process fit from a team that knows halogenated anilides.
One point of contact
Source 2-B-4-FAA alongside your other intermediates — one enquiry, one team, one invoice.
Ordering
How to order 2-Bromo-4-Fluoro Acetanilide from Chelora
Ordering is simple and fast — most enquiries are answered with pricing and availability within 24 hours.
- 1
Send your enquiry
Tell us the grade, quantity and application you are buying for.
- 2
Receive a quotation
We send pricing along with the COA and MSDS for your review.
- 3
Request a sample
Test suitability for your process before you commit to a bulk order.
- 4
Confirm the order
Lock in quantity, packaging and delivery preference.
- 5
Dispatch & tracking
We dispatch with full documentation and keep you updated until delivery.
Documentation
2-Bromo-4-Fluoro Acetanilide MSDS & COA
A summary of key safety information and a representative Certificate of Analysis. The complete 16-section Safety Data Sheet and the actual batch COA are supplied with each shipment — and both are sent with your quotation when you ask for a quote.
Safety data summary (MSDS)
| Section | Details |
|---|---|
| Hazard classification | Acute toxicity cat. 4 (oral / dermal / inhalation); skin irritation cat. 2; eye irritation cat. 2; STOT SE cat. 3 (respiratory irritation) |
| Signal word | Warning |
| First aid — inhalation | Move to fresh air; keep at rest; get medical advice if symptoms persist |
| First aid — skin | Remove contaminated clothing; wash thoroughly with soap & water |
| First aid — eyes | Rinse with water for several minutes; get medical advice |
| Handling | Use PPE; control dust; ventilate; avoid skin and eye contact |
| Storage | Cool, dry, sealed and dark; away from oxidisers & strong bases |
| Environment | Prevent release to drains, soil and waterways |
| Transport | Confirmed on the supplier SDS and shipping documents |
Certificate of Analysis (representative)
| Test parameter | Specification | Method |
|---|---|---|
| Assay (purity) | 98% min | HPLC |
| Appearance | White to off-white powder | Visual |
| Melting range | 117–119 °C | Capillary |
| Isomeric bromo compounds | 0.5% max | HPLC |
| Moisture | 0.5% max | Karl Fischer |
| Residue on ignition | 0.1% max | Gravimetric |
The actual batch COA is supplied with each shipment.
FAQ
Frequently asked questions
Common questions from buyers specifying 2-B-4-FAA for pharmaceutical, agrochemical and contract research synthesis.
What is 2-Bromo-4-Fluoro Acetanilide used for?
2-B-4-FAA is used as a protected building block for fluorinated heterocycles. The bromine is consumed in palladium cross-coupling or halogen–metal exchange, the acetyl group is then hydrolysed to free the aniline, and the resulting amine closes onto indole, indazole, benzimidazole, benzothiazole or quinazoline ring systems used in pharmaceutical and agrochemical actives.
What is the CAS number of 2-B-4-FAA?
The CAS number is 1009-22-9 and the molecular formula is C8H7BrFNO, with a molecular weight of 232.05 g/mol. Its EC number is 600-141-3 and the IUPAC name is N-(2-bromo-4-fluorophenyl)acetamide.
How is 2-Bromo-4-Fluoro Acetanilide made?
4-Fluoroaniline is acetylated with acetic anhydride to give 4-fluoroacetanilide, which is then brominated under controlled temperature. The acetamido group directs the bromine to the adjacent ring position, and the product is isolated by crystallisation.
Why protect the aniline as an acetanilide?
A free aromatic amine interferes with the chemistry that follows: it poisons palladium catalysts, is itself attacked by brominating agents, and makes regiocontrol much harder. Capping it as the acetamide tames the nitrogen, directs bromination to the position next to it, and comes off cleanly by hydrolysis once the coupling step is done.
Is 2-Bromo-4-Fluoro Acetanilide hazardous?
Yes. It is harmful if swallowed, in contact with skin or if inhaled, and irritates the eyes, skin and respiratory system. It is also a combustible solid. Handle it with PPE and dust extraction; we supply a full MSDS with every order.
How should 2-B-4-FAA be stored?
In sealed drums in a cool, dry, well-ventilated store, away from heat, direct light, strong oxidisers and strong bases. Keep containers closed between uses so the powder stays dry and free-flowing.
Do you provide COA and MSDS for 2-B-4-FAA?
Yes, we provide a batch-specific COA and MSDS with every order, plus technical support on request.
Do you supply and export 2-Bromo-4-Fluoro Acetanilide?
Yes, we supply 2-B-4-FAA across India and export internationally with complete documentation, sourced from reliable manufacturers.
Request a quote or sample
Need a reliable 2-B-4-FAA supplier?
Looking for a dependable 2-Bromo-4-Fluoro Acetanilide (2-B-4-FAA) supplier and distributor — in India or anywhere we export to? Tell us the grade and quantity you need — our team responds with competitive bulk pricing, samples and complete documentation (COA, MSDS, TDS) within 24 hours.
Or email source@cheloraagrochem.com